IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00025285" target="_blank" >RIV/00216224:14310/08:00025285 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
Original language description
Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. In our previous in vitro study, we have described interaction of HS with AhR5, which has been also confirmed in vivo6. In this contribution, we summarize our new findings on interaction of both AhR-active and -inactive HS with 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD). We have observed decrease of TCDD-caused AhR-mediated effect at very high amounts of both TCDD and AhR-active HS. On the other hand, AhR-mediated effect was rather additive at lower concentrations of both TCDD and AhR-active HS. The possible mechanisms are discussed.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
DJ - Pollution and water control
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP525%2F08%2FP464" target="_blank" >GP525/08/P464: Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů