Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00042180" target="_blank" >RIV/00216224:14310/08:00042180 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)
Original language description
The polymorphism of major histocompatibility complex (MHC) genes was investigated in relation to parasitism in several populations of chub (Leuciscus cephalus) from different European rivers. The MHC genes are the most polymorphic loci known for vertebrates, whereas tree possible hypotheses of parasite-mediated selection driving an extensive MHC diversity (i.e. overdominance hypothesis, frequency dependent selection hypothesis and hypothesis of optimal number of MHC alleles) have been proposed. Hence, these genes are convenient model for elucidating the host-parasite relationships. It has been predicted that the populations with more genetic variability of MHC will have more diverse array of parasites. The antigens derived from parasites (possible important selective agents) interact with peptide binding region of MHC II molecules, on that account the present study was focused on genetic variability of the exon 2 (DAB1 and DAB3 genes), which encodes the beta 1 domain of the peptide bin
Czech name
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Czech description
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Project
<a href="/en/project/LC522" target="_blank" >LC522: ICHTHYOPASITOLOGY RESEARCH CENTRE</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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