Architecture and activities of Structure Maintenance of Chromosome SMC5/6 complex
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00028719" target="_blank" >RIV/00216224:14310/09:00028719 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Architecture and activities of Structure Maintenance of Chromosome SMC5/6 complex
Original language description
SMC complexes (Structural Maintenance of Chromosomes)contribute to organization and maintenance of chromatin structure. SMC1/3 cohesin complex holds sister chromatids untill the onset of anaphase. Condensin complex is essential for condensing intephase chromosomes prior a mitosis. The third SMC5/6 complex is multifunctional - participates in e.g. DNA repair. SMC5/6 contains the most subunits: e.g. Nse2 is a SUMO ligase and Nse3 subunit is a funding member of MAGE (melanoma antigen) family of proteins. More then 50 genes (and/or pseudogenes) comprise the MAGE superfamily in human genome. Most of them are expressed in specific cancer/testis manner. Although a little is known about their function all available data indicate their important role in regulation of cellular processes and cancer genesis.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA501630902" target="_blank" >IAA501630902: Characterization of MAGE proteins: cofactors for E3 ubiquitin ligases?</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů