Differences in conformational behavior of amyloid beta in solvent with different ionic strength
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00029983" target="_blank" >RIV/00216224:14310/09:00029983 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Differences in conformational behavior of amyloid beta in solvent with different ionic strength
Original language description
INTRODUCTION Amyloid beta-peptide (Abeta) is the major component of plaques found in the brains of Alzheimers patients. Among its two predominate forms - Abeta(1-40) and Abeta(1-42), the latter possesses stronger aggregation and deposition propensity than the former. To explore the conformational preference of Abeta(1-42) in solvent with different ionic strength, molecular dynamics (MD) simulations were performed. METHODS The human Abeta(1-42) structure presented in PDB database (code 1Z0Q) was used asstarting point for MD simulations. The rat structure was prepared from human by mutation of 3 residues using Modeller software. The input structures were solvated by program SOLVATE and sodium and chloride ions in different concentrations were added to the system. For each system, 50 ns long trajectory was run and stability of the secondary structures of the protein was investigated.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
34th Congress of the Federation-of-European-Biochemical-Societies
ISBN
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ISSN
1742-464X
e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Wiley-Blackwell
Place of publication
Oxford
Event location
Praha
Event date
Jan 1, 2009
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000267069900418