Burkholderia cenocepacia and its novel two domain superlectin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00036622" target="_blank" >RIV/00216224:14310/09:00036622 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Burkholderia cenocepacia and its novel two domain superlectin
Original language description
Burkholderia cenocepacia is a Gram-negative bacterium that can be found throughout the environment. It is a part of "Burkholderia cepacia complex", which causes potentially deadly problems to patients suffering from cystic fibrosis and chronic granulomatous diseases. A goal of primary importance of this study is the understanding of the molecular mechanisms, especially protein-carbohydrate interactions, which give pathogenic bacterium the ability to invade and colonize its host. Four genes coding protein homologues to the lectin PA-IIL from Pseudomonas aeruginosa have been found in the genome of B. cenocepacia. One of them, BclC, is a 28 kDa protein. The results indicated the unusual binding activity of the protein. The C-terminal domain recognizes D-mannosylated saccharides. Interestingly, the N-terminal domain also displays sugar-binding activity with a strong preference for L-fucosylated oligosaccharides, the Lewis type determinants.
Czech name
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Czech description
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Project
<a href="/en/project/LC06030" target="_blank" >LC06030: Biomolecular centre</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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