How do cryptosporidia establish their unique niche within the host epithelium?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00037136" target="_blank" >RIV/00216224:14310/09:00037136 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
How do cryptosporidia establish their unique niche within the host epithelium?
Original language description
Cryptosporidia are significant vertebrate pathogens with unique invasion strategy, which, together with phylogenetic analyses suggest a close affinity to gregarines. Electron microscopic observations on 2 evolutionarily distinct gastric species, Cryptosporidium muris from experimentally infected rodents and C. fragile from naturally infected toads, allowed us to map ultrastructural aspects of the cryptosporidian invasion process along with the origin and architecture of parasitophorous sac, and to generalize these observations for gastric cryptosporidia. Both species exhibit a comparable strategy of host cell invasion in which they do not penetrate under the host cell plasma membrane, nor do they come into close contact with the host cytoplasm. Parasite remains attached to the host cell surface, only enveloped by the host membrane folds. Thus, the term epicellular more accurately defines the host compartment within which cryptosporidia reside than does the term intracellular-extracytop
Czech name
—
Czech description
—

Project
<a href="/en/project/LC522" target="_blank" >LC522: ICHTHYOPASITOLOGY RESEARCH CENTRE</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)