Metal complexes of macrocyclic ligands mimicking enzyme activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00037452" target="_blank" >RIV/00216224:14310/09:00037452 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Metal complexes of macrocyclic ligands mimicking enzyme activity
Original language description
Metal ions form with macrocyclic ligands more stable complexes than with analogous acyclic ligands from both thermodynamic and kinetic point of view. These complexes can be studied as suitable models in order to mimic the metaloenzyme activity. In this contribution, the catalytic activity of [M(cyclen)]2+ complexes (M = Zn, Cd, Cu, Ni, cyclen = 1,4,7,10-tetraazacyclodecane, [12]aneN4) which are mimicking enzymes was investigated for hydrolysis of acetic acid esters acting as substrate. The rate of esterhydrolysis was monitored by molecular absorption (for 4-nitrophenylacetate) or luminescence (for 4-methylumbelliferylacetate) spectroscopy and optimal experimental conditions (e.g. temperature, pH, buffer, etc.) were found. The catalytic activity of themost active Zn(II) and Cd(II) metal complexes is inhibited by some compounds due to formation of stable ternary complexes. The influence of various inhibiting agents (mostly base, e.g.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstract Book of ISABC 10 conference (International Symposium on Applied Bioinorganic Chemistry)
ISBN
978-963-473-307-2
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Department of Inorganic and Analytical Chemistry, Debrecen University
Place of publication
Debrecen
Event location
Debrecen
Event date
Jan 1, 2009
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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