Computational Study of MutH Recognition and Catalysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00039550" target="_blank" >RIV/00216224:14310/09:00039550 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Computational Study of MutH Recognition and Catalysis
Original language description
MutH enzyme participates in methyl-directed DNA repair together with two other enzymes MutS and MutL. Their joint choreography is conceptually known but a lot of details are still elusive. We aim to resolve to two challenging questions related to the recognition and catalytic activity of MutH by utilizing computational techniques. 1) How a single methyl group attached to a far-lying adenine base from the active site can determine the activity of MutH? 2) Is Lys-77 residue serves to couple recognition tocatalysis?
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů