Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040731" target="_blank" >RIV/00216224:14310/10:00040731 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study
Original language description
There is accumulating evidence that disturbances in the N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (8 isoforms altogether) as well as the mRNA individual isoforms in the post-mortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Therewere no significant differences in the panGluN1subunit mRNA expression, but the absolute left-right differences were much more pronounced in the patients with schizophrenia. Protein levels of the GluN1 subunit in the left hippocampus in male schizophrenic patients were lower in comparison with controls. The expression of the NR1-4b isoform was attenuated in the left whereas the NR1-2b was reduced in the right hippocampus of schizophrenic patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9324" target="_blank" >NR9324: The candidate genes for schizophrenia: the influence on phenotypic variability in patients and in vitro manipulation of gene expression by the use of siRNA.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurochemical Research
ISSN
0364-3190
e-ISSN
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Volume of the periodical
2010
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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