Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00046189" target="_blank" >RIV/00216224:14310/10:00046189 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms
Original language description
Ln(III) complexes of macrocyclic ligand H4dota and its derivatives are utilized in many areas of medicinal chemistry. Crucial factor for MRI and luminescence probes is determination of the number of the water molecules coordinated to Ln(III) complex, then its thermodynamic stability and kinetic inertness of the complexes. Time-resolved luminescence spectroscopy of Eu(III) ion and its complexes with macrocyclic DOTA-like ligands as model Ln(III) complexes in solutions for measurement of luminescence decay is used for the determination of the number of water molecules in the first coordination sphere. This measurement can be used for estimation of the number of coordinated water molecules in the course of Eu(III) complexation by ligands or Eu(III) complex dissociation in order to propose its reaction mechanism. The achieved results can be utilized for optimization of ligand structure for Ln(III) fast complexation/slow decomplexation.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstract Book of XIV. International Symposium on Luminescence Spectrometry
ISBN
978-80-254-6830-2
ISSN
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e-ISSN
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Number of pages
216
Pages from-to
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Publisher name
Faculty of Pharmacy, Charles University, Prague
Place of publication
Praha
Event location
Praha
Event date
Jul 13, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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