Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00046190" target="_blank" >RIV/00216224:14310/10:00046190 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents
Original language description
Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine. The molecular spectroscopy in UV/VIS region was employed to investigate chemical features of Eu(III)/Gd(III)/Tb(III) complexes of the title ligand in order to investigate their possible applications as bimodal agents. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. In the study of formation (pH = 5.0-6.0, t = 25 C, I = 0.1 M KCl) wasfound that the reactive species is HL 2- and the rate increases with decreasing ionic radius of the metal ions and it follows a trend along the Ln(III) series. The ligand capable of complex formation due show interesting photophysical properties to presence of chromophor/fluorophor group and it enables to determine the low concentration of Eu(III)/Tb(III) ions.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstract book of XIV. Symposium on Luminescence Spectrometry
ISBN
978-80-254-6830-2
ISSN
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e-ISSN
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Number of pages
216
Pages from-to
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Publisher name
Faculty of Pharmacy, Charles University Prague
Place of publication
Praha
Event location
Praha
Event date
Jul 13, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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