Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00062482" target="_blank" >RIV/00216224:14310/11:00062482 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106" target="_blank" >http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chemphyslip.2011.05.106" target="_blank" >10.1016/j.chemphyslip.2011.05.106</a>

Result language
angličtina
Original language name
Docosahexaenoic acid sensitizes colon cancer cells to apoptotic effect of TRAIL by modulation of lipid and apoptotic signalling pathways
Original language description
Recently, it is suggested that some dietary polyunsaturated fatty acids (PUFAs) play an important role in suppression of colon cancer. Namely n-3 PUFAs, such as docosahexaenoic acid (DHA), showed antiproliferative and apoptotic effects in colon cancer cells. However, DHA is preferentially considered as supporting agent in combined anticancer therapy. TNF-related Apoptosis Inducing Ligand (TRAIL) is cytokine able to induce apoptosis in cancer cells with little effect on normal cells. It is promising forcancer treatment, but some cancer cells appeared to be resistant to TRAIL-induced apoptosis. We showed that pretreatment with physiological doses of DHA results in significantly enhanced TRAIL-induced apoptosis of otherwise resistant human colon cells asdocumented by increased caspase activation and cleavage of their substrates. We demonstrated activation of crucial mitochondrial proapototic molecules, such as Bax and Bak.
Czech name
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Czech description
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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