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Supramolecular complexes formation. Possibilities of mass spectrometric studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00059907" target="_blank" >RIV/00216224:14310/12:00059907 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.euchems-prague2012.cz/" target="_blank" >http://www.euchems-prague2012.cz/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Supramolecular complexes formation. Possibilities of mass spectrometric studies

  • Original language description

    In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest &lt;=&gt; {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů