Do cyanobacteria produce estrogenic compounds?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F12%3A00067012" target="_blank" >RIV/00216224:14310/12:00067012 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Do cyanobacteria produce estrogenic compounds?
Original language description
Number of studies document hazardous potential of cyanobacterial metabolites.Despite the observed effects on reproduction related parameters, growth and development,there is little information on endocrine disruptive potential of compounds from cyanobacteria.Our research aimed to determine if complex water bloom of cyanobacteria collected from the environment contain compounds that would interact with the signaling pathways of arylhydrocarbon receptor (AhR), androgenic receptor (AR), estrogenic receptor(ER),glucocorticoid receptor (GR) or retinoid acid receptor (RAR).In vitro reporter gene trans-activation assays were used to determine the potency of samples to elicit receptor-mediated responses.Estrogenicity was detected for most environmental samples, their estimated estrogenic equivalents ranged from 19 to 2200 ng 17b-estradiol /g dw.Some of them also interfered with the signalling of androgen receptor.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
DJ - Pollution and water control
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů