Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00066087" target="_blank" >RIV/00216224:14310/13:00066087 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/13:00428602

Result on the web

<a href="http://dx.doi.org/10.1016/j.psychres.2012.08.003" target="_blank" >http://dx.doi.org/10.1016/j.psychres.2012.08.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psychres.2012.08.003" target="_blank" >10.1016/j.psychres.2012.08.003</a>

Result language

angličtina

Original language name

Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes

Original language description

The results of linkage and candidate gene association studies have led to a range of hypotheses about the pathogenesis of schizophrenia. We limited our study to polymorphisms in candidate genes involved in dopaminergic and noradrenergic systems, and in the 25 KDa synaptosomal-associated protein (SNAP-25) gene that is related to neurotransmitter exocytosis. Eight single nucleotide polymorphisms (SNPs) in regulating or coding regions of genes for the alpha-2A adrenergic receptor (ADRA2A), dopamine receptors D1 and D3 (DRD1 and DRD3), dopamine beta-hydroxylase (DBH) and SNAP-25 were genotyped in male patients with schizophrenia (n=192) and in healthy controls (n=213). These polymorphisms were previously associated with schizophrenia. The allelic association between schizophrenia and ADRA2A rs1800544 polymorphism, SNAP-25 rs1503112 polymorphism, and DRD3 rs6280 polymorphism was found in our study. However, only obseivations for rs1503112 survived correction for multiple testing.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GP309%2F09%2FP361" target="_blank" >GP309/09/P361: Relationship of candidate genes polymorphisms interaction to pathogenesis of schizophrenia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatry Research

ISSN

0165-1781

e-ISSN

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Volume of the periodical

205

Issue of the periodical within the volume

1-2

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

7-12

UT code for WoS article

000315252500002

EID of the result in the Scopus database

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