The endocrine disruptive potential of phytoplankton exudates.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00067014" target="_blank" >RIV/00216224:14310/13:00067014 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The endocrine disruptive potential of phytoplankton exudates.
Original language description
This study focus on endocrine disrupting potential of metabolites with high environmental relevance which phytoplankton excrete into the surrounding environment during normal physiological processes (exudates). The novel embryo model with transgenic zebrafish strain (cyp19a1b-GFP) was chosen to assess the in vivo estrogenicity. Green fluorescent protein (GFP) is expresses under the control of aromatase B (cyp19a1b) promoter which is induced by estrogens. Phenotypic toxicity and neurotoxicity was also assessed in zebrafish embryos. Battery of in vitro methods focused on diverse endocrine disruption modes of action ? estrogenic, anti/androgenic, glucocorticoid and anti/retinoid was used to investigate potential effects on receptor level. Concentrations of a set of prioritised phytoestrogens were determined analytically by HPLC-MSMS to investigate to which extent they could be responsible for the observed biological effects.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
DJ - Pollution and water control
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů