The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00067038" target="_blank" >RIV/00216224:14310/13:00067038 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pbio.1001562" target="_blank" >http://dx.doi.org/10.1371/journal.pbio.1001562</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pbio.1001562" target="_blank" >10.1371/journal.pbio.1001562</a>
Alternative languages
Result language
angličtina
Original language name
The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling.
Original language description
Wnt Planar Cell Polarity (PCP) signaling is a universal regulator of polarity in epithelial cells, but it regulates axon outgrowth in neurons, suggesting the existence of axonal modulators of Wnt-PCP activity. The Amyloid precursor proteins (APPs) are intensely investigated because of their link to Alzheimer's disease (AD). APP's in vivo function in the brain and the mechanisms underlying it remain unclear and controversial. Drosophila possesses a single APP homologue called APP Like, or APPL. APPL is expressed in all neurons throughout development, but has no established function in neuronal development. We therefore investigated the role of Drosophila APPL during brain development. We find that APPL is involved in the development of the Mushroom Bodyalfa beta neurons and, in particular, is required cell-autonomously for the beta-axons and non-cell autonomously for the alfa-axons growth.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Biology
ISSN
1544-9173
e-ISSN
—
Volume of the periodical
2013
Issue of the periodical within the volume
11(5)
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
"e1001562"
UT code for WoS article
—
EID of the result in the Scopus database
—