The mechanism of response to hypoxia in embryonic stem cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00070747" target="_blank" >RIV/00216224:14310/13:00070747 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
The mechanism of response to hypoxia in embryonic stem cells
Original language description
Oxygen is a crucial element for life of most organisms. Key regulator of oxygen sensing and responding intracellular machinery is heterodimeric transcription factor HIF1 (hypoxia inducible factor 1). Presence of oxygen leads to rapid ubiquitination and proteozomal degradation of cytoplasmic subunit HIF1alpha. This process is abolished in hypoxia, leading to accumulation of alpha subunit and dimerization with HIF1beta (also called ARNT). Upon binding of HIF1 heterodimer to hypoxia responsive elements, transcription of many specific genes involved in oxygen homeostasis is induced (Wang et al., 1995). Moreover hypoxia increases a production of intracellular reactive oxygen species (ROS) (Chandel et al., 2002). ROS can modulate cell signaling through transcription and also through posttranslational modifications of intracellular signaling pathways (Finkel, 2011). Additionally, further mechanisms of low oxygen sensing excluding the involvement of HIF and ROS were reported (Wouters and Korit
Czech name
—
Czech description
—

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)