Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00073568" target="_blank" >RIV/00216224:14310/14:00073568 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00427939
Result on the web
<a href="http://dx.doi.org/10.1126/scisignal.2004985" target="_blank" >http://dx.doi.org/10.1126/scisignal.2004985</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/scisignal.2004985" target="_blank" >10.1126/scisignal.2004985</a>
Alternative languages
Result language
angličtina
Original language name
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway.
Original language description
Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/beta-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellularlocalization, or interactions of target proteins. To identify regulators of the Wnt/beta-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain-containing ubiquitin ligase EEL-1 as an inhibitor of Wnt signaling. In human embryonic kidney 293T cells, knockdown of the EEL-1 homolog Huwe1 enhanced the activity of a Wnt reporter in cells stimulated with Wnt3a or in cells that overexpressed casein kinase 1 (CK1) or a constitutively active mutant of the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Signaling
ISSN
1937-9145
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
317
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"ra26"
UT code for WoS article
000333557500002
EID of the result in the Scopus database
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