Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00074977" target="_blank" >RIV/00216224:14310/14:00074977 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/14:#0000504
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pmic.201300264/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pmic.201300264" target="_blank" >10.1002/pmic.201300264</a>
Alternative languages
Result language
angličtina
Original language name
Proteomics in investigation of cancer metastasis: Functional and clinical consequences and methodological challenges.
Original language description
Metastases are responsible for most of the cases of death in patients with solid tumors. There is thus an urgent clinical need of better understanding the exact molecular mechanisms and finding novel therapeutics targets and biomarkers of metastatic disease of various tumors. Metastases are formed in a complicated biological process called metastatic cascade. Up to now, proteomics has enabled the identification of number of metastasis-associated proteins and potential biomarkers in cancer tissues, microdissected cells, model systems, and secretomes. Expression profiles and biological role of key proteins were confirmed in verification and functional experiments. This communication reviews these observations and analyses the methodological aspects of the proteomics approaches used. Moreover, it reviews contribution of current proteomics in the field of functional characterization and interactome analysis of proteins involved in various events in metastatic cascade.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proteomics
ISSN
1615-9853
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
4-5
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
426-440
UT code for WoS article
000332341200008
EID of the result in the Scopus database
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