Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00107105" target="_blank" >RIV/00216224:14310/14:00107105 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/14:00435406 RIV/00159816:_____/14:00061023

Result on the web

<a href="http://downloads.hindawi.com/journals/mi/2014/694312.pdf" target="_blank" >http://downloads.hindawi.com/journals/mi/2014/694312.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/694312" target="_blank" >10.1155/2014/694312</a>

Result language

angličtina

Original language name

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions

Original language description

The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress. Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions. These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases. In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels. The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination. In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized. Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

1466-1861

Volume of the periodical

25

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

17

Pages from-to

1-17

UT code for WoS article

000334284300001

EID of the result in the Scopus database

2-s2.0-84899416510