Efficient solid support catalyzed mono-aza-Michael addition reactions of piperazine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00081733" target="_blank" >RIV/00216224:14310/15:00081733 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00706-014-1379-2" target="_blank" >http://dx.doi.org/10.1007/s00706-014-1379-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-014-1379-2" target="_blank" >10.1007/s00706-014-1379-2</a>

Result language

angličtina

Original language name

Efficient solid support catalyzed mono-aza-Michael addition reactions of piperazine

Original language description

We report new methods for the efficient mono-aza-Michael additions of piperazine to compounds with activated multiple carbon?carbon bond (functional derivatives of acrylic, propiolic, and acetylenedicarboxylic acid). This method is based on the reactionof piperazine-1-ium cation with alkenes or alkynes substituted by EWGs under catalysis by various metal ions supported on weakly acidic cation-exchanger resin. Starting piperazine-1-ium cation is generated in situ in methanol solution by mixing of piperazine and piperazine-1,4-diium dichloride in various ratios. It was found that solid support metal catalysis afforded target products in very good yields in shortened reaction times. A new method of N-monosubstituted piperazine derivative preparation is very beneficial, because until now no one has come up with the idea to use for protection of the one nitrogen atom of the piperazine its simple protonation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/2A-1TP1%2F090" target="_blank" >2A-1TP1/090: New catalysts and reagents for sustainable green syntheses and combinatorial syntheses</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

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Volume of the periodical

146

Issue of the periodical within the volume

4

Country of publishing house

AT - AUSTRIA

Number of pages

9

Pages from-to

653-661

UT code for WoS article

000351279800015

EID of the result in the Scopus database

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