Truncated tau deregulates synaptic markers in rat model for human tauopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00082410" target="_blank" >RIV/00216224:14310/15:00082410 - isvavai.cz</a>

Result on the web

<a href="http://journal.frontiersin.org/article/10.3389/fncel.2015.00024/abstract" target="_blank" >http://journal.frontiersin.org/article/10.3389/fncel.2015.00024/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fncel.2015.00024" target="_blank" >10.3389/fncel.2015.00024</a>

Result language

angličtina

Original language name

Truncated tau deregulates synaptic markers in rat model for human tauopathy

Original language description

Synaptic failure and neurofibrillary degeneration are two major neuropathological substrates of cognitive dysfunction in Alzheimer?s disease (AD). Only a few studies have demonstrated a direct relationship between these two AD hallmarks. To investigate tau mediated synaptic injury we used rat model of tauopathy that develops extensive neurofibrillary pathology in the cortex. Using fractionation of cortical synapses, we identified an increase in endogenous rat tau isoforms in presynaptic compartment, andtheir mis-sorting to the postsynaptic density (PSD). Truncated transgenic tau was distributed in both compartments exhibiting specific phospho-pattern that was characteristic for each synaptic compartment. In the presynaptic compartment, truncated tau was associated with impairment of dynamic stability of microtubules which could be responsible for reduction of synaptic vesicles. In the PSD, truncated tau lowered the levels of neurofilaments.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BB - Applied statistics, operational research

OECD FORD branch

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Project

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Continuities

O - Projekt operacniho programu

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Cellular Neuroscience

ISSN

1662-5102

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

February

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

"nestránkováno"

UT code for WoS article

000349956300001

EID of the result in the Scopus database

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