The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00083055" target="_blank" >RIV/00216224:14310/15:00083055 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/15:00446223 RIV/61989592:15310/15:33155397 RIV/00027162:_____/15:#0001342

Result on the web

<a href="http://dx.doi.org/10.1016/j.tox.2015.04.001" target="_blank" >http://dx.doi.org/10.1016/j.tox.2015.04.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2015.04.001" target="_blank" >10.1016/j.tox.2015.04.001</a>

Result language

angličtina

Original language name

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

Original language description

Inhibition of apoptosis by the ligands of the aryl hydrocarbon receptor (AhR) has been proposed to play a role in their tumor promoting effects on liver parenchymal cells. However, little is presently known about the impact of toxic AhR ligands, such as2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on apoptosis in other liver cell types, such as in liver epithelial/progenitor cells. In the present study, we focused on the effects of TCDD on apoptosis regulation in a model of liver progenitor cells, rat WB-F344 cell line, during the TCDD-elicited release from contact inhibition. The stimulation of cell proliferation in this cell line was associated with deregulated expression of a number of genes known to be under transcriptional control of the Hippo signaling pathway, a principal regulatory pathway involved in contact inhibition of cell proliferation.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

<a href="/en/project/GA13-07711S" target="_blank" >GA13-07711S: The role of Hippo signaling pathway and organic toxicants in alterations of liver cell function and xenobiotic metabolism</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology

ISSN

0300-483X

e-ISSN

—

Volume of the periodical

333

Issue of the periodical within the volume

July

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

37-44

UT code for WoS article

000357228200004

EID of the result in the Scopus database

—