Cysteine peptidase inhibitors of Trichinella spiralis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00084265" target="_blank" >RIV/00216224:14310/15:00084265 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cysteine peptidase inhibitors of Trichinella spiralis
Original language description
Trichinella spriralis is well known causative agent of human disease trichinellosis. Individuals of this nematode parasite produce various types of cysteine peptidase inhibitors (cystatins) in order to regulate the function of cysteine peptidases and modulate the immune response of the host organism. Therefore we aim to reveal the differences in production of cystatin by different T. spiralis developmental stages. Three types of cystatins were identified in the genome of T. spiralis cystatin B, onchocystatin and multi cystatin domain protein. ICR and SCID mice were experimentally infected per os with infective muscle stage larvae (ML) of T. spiralis. Preadults (Ad3), adults (Ad5), new born larvae (NBL) and muscle stage (ML) larvae of T. spiralis were isolated from the intestinal and muscle tissue at various time post infection. Excretory/secretory products of all developmental stages were isolated and screened for the presence of cystatins using mass spectrometry.
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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