Nestin as a marker of cancer stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00084859" target="_blank" >RIV/00216224:14310/15:00084859 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/15:#0000653
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/cas.12691/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/cas.12691/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cas.12691" target="_blank" >10.1111/cas.12691</a>
Alternative languages
Result language
angličtina
Original language name
Nestin as a marker of cancer stem cells
Original language description
The crucial role of cancer stem cells (CSCs) in the pathology of malignant diseases has been extensively studied during the last decade. Nestin, a class VI intermediate filament protein, was originally detected in neural stem cells during development. Its expression has also been reported in different tissues under various pathological conditions. Specifically, nestin has been shown to be expressed in transformed cells of various human malignancies, and a correlation between its expression and the clinical course of some diseases has been proved. Furthermore, the coexpression of nestin with other stem cell markers was described as a CSC phenotype that was subsequently verified using tumorigenicity assays. The primary aim of this review is to summarizethe recent findings regarding nestin expression in CSCs, its possible role in CSC phenotypes, particularly with respect to capacity for self-renewal, and its utility as a putative marker of CSCs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Science
ISSN
1347-9032
e-ISSN
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Volume of the periodical
106
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
803-811
UT code for WoS article
000357883900003
EID of the result in the Scopus database
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