Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086751" target="_blank" >RIV/00216224:14310/15:00086751 - isvavai.cz</a>

Result on the web

<a href="http://pubs.acs.org/doi/10.1021/acs.est.5b04083" target="_blank" >http://pubs.acs.org/doi/10.1021/acs.est.5b04083</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.est.5b04083" target="_blank" >10.1021/acs.est.5b04083</a>

Result language

angličtina

Original language name

Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling

Original language description

Surface water can contain countless organic micropollutants, and targeted chemical analysis alone may only detect a small fraction of the chemicals present. Consequently, bioanalytical tools can be applied complementary to chemical analysis to detect theeffects of complex chemical mixtures. In this study, bioassays indicative of activation of the aryl hydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen receptor (ER), adaptive stress responses to oxidativestress (Nrf2), genotoxicity (p53) and inflammation (NF-kappa B) and the fish embryo toxicity test were applied along with chemical analysis to water extracts from the Danube River. Mixture-toxicity modeling was applied to determine the contribution of detected chemicals to the biological effect. Effect concentrations for between 0 to 13 detected chemicals could be found in the literature for the different bioassays. Detected chemicals explained less than 0.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DJ - Pollution and water control

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ENVIRONMENTAL SCIENCE &amp; TECHNOLOGY

ISSN

0013-936X

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

24

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

14614-14624

UT code for WoS article

000366872300085

EID of the result in the Scopus database

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