High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00093841" target="_blank" >RIV/00216224:14310/15:00093841 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0014482715301336" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0014482715301336</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yexcr.2015.10.022" target="_blank" >10.1016/j.yexcr.2015.10.022</a>
Alternative languages
Result language
angličtina
Original language name
High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes
Original language description
Malignant gliomas are among the most severe types of cancer, and the most common primary brain tumors. Treatment options are limited and the prognosis is poor. WNT-5A, a member of the WNT family of lipoglycoproteins, plays a role in oncogenesis and tumor progression in various cancers, whereas the role of WNT-5A in glioma remains obscure. Based on the role of WNT-5A as an oncogene, its potential to regulate microglia cells and the glioma-promoting capacities of microglia cells, we hypothesize that WNT-5A has a role in regulation of immune functions in glioma. We investigated WNT-5A expression by in silico analysis of the cancer genome atlas (TCGA) transcript profiling of human glioblastoma samples and immunohistochemistry experiments of human glioma tissue microarrays (TMA). Our results reveal higher WNT-5A protein levels and mRNA expression in a subgroup of gliomas (WNT-5A(high)) compared to non-malignant control brain tissue.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/EE2.3.20.0180" target="_blank" >EE2.3.20.0180: Cooperation between Masaryk University and Karolinska Institutet, Stockholm in the field of biomedicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental cell research
ISSN
0014-4827
e-ISSN
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Volume of the periodical
339
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
280-288
UT code for WoS article
000366618700012
EID of the result in the Scopus database
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