Double strand breaks may be a missing link between entropy and aging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00090377" target="_blank" >RIV/00216224:14310/16:00090377 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.mad.2016.06.002" target="_blank" >http://dx.doi.org/10.1016/j.mad.2016.06.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mad.2016.06.002" target="_blank" >10.1016/j.mad.2016.06.002</a>
Alternative languages
Result language
angličtina
Original language name
Double strand breaks may be a missing link between entropy and aging
Original language description
It has been previously suggested that an increase in entropy production leads to aging. However, the mechanisms linking increased entropy production in living mass to aging are currently unclear. Even though entropy cannot be easily associated with any specific molecular damage, the increase of entropy in structural mass may be connected with heat stress, which is known to generate double strand breaks. Double strand breaks, which are in turn known to play an important role in process of aging, are thus connected to both aging and an increase of entropy. In view of these associations, we propose a new model where the increase of entropy leads to the formation of double strand breaks, resulting in an aging phenotype. This not only offers a new perspective on aging research and facilitates experimental validation, but could also serve as a useful explanatory tool.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LM2011028" target="_blank" >LM2011028: RECETOX ? National research infrastructure for toxic compounds in the environment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mechanisms of Ageing and Development
ISSN
0047-6374
e-ISSN
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Volume of the periodical
157
Issue of the periodical within the volume
July
Country of publishing house
IE - IRELAND
Number of pages
6
Pages from-to
1-6
UT code for WoS article
000383303000001
EID of the result in the Scopus database
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