Cystatins of the parasitic nematodes Trichinella spiralis and T. pseudospiralis: xMAP technology in serodiagnostics.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00091092" target="_blank" >RIV/00216224:14310/16:00091092 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Cystatins of the parasitic nematodes Trichinella spiralis and T. pseudospiralis: xMAP technology in serodiagnostics.

Original language description

Nematodes of the genus Trichinella are clinically important parasites invading cells of the small intestine and subsequently skeletal muscles. Their global distribution is corresponding to the wide range of their hosts involving birds, reptiles and mammals. Seven (T1, T2, T3, T4, T5, T6 a T10) of twelve genotypes of Trichinella spp. are zoonoses causing the trichinellosis - a serious and sometimes fatal human disease. During the life cycle, the individuals of this nematode parasite release variety of functional molecules, which are mainly present in excretory-secretory (E-S) products. These molecules are essential for many biological processes like development, digestion, migration, and also in manipulation of the host immunne system. The most dominant components of the E-S products are cystatins – inhibitors of cysteine peptidases of C1 and rarely of C13 family. Our work is focused on the characterization of „multi cystatin-like domain“ (mcd-1) genes and proteins of Trichinella spiralis and T.

Czech name

Cystatins of the parasitic nematodes Trichinella spiralis and T. pseudospiralis: xMAP technology in serodiagnostics.

Czech description

Nematodes of the genus Trichinella are clinically important parasites invading cells of the small intestine and subsequently skeletal muscles. Their global distribution is corresponding to the wide range of their hosts involving birds, reptiles and mammals. Seven (T1, T2, T3, T4, T5, T6 a T10) of twelve genotypes of Trichinella spp. are zoonoses causing the trichinellosis - a serious and sometimes fatal human disease. During the life cycle, the individuals of this nematode parasite release variety of functional molecules, which are mainly present in excretory-secretory (E-S) products. These molecules are essential for many biological processes like development, digestion, migration, and also in manipulation of the host immunne system. The most dominant components of the E-S products are cystatins – inhibitors of cysteine peptidases of C1 and rarely of C13 family. Our work is focused on the characterization of „multi cystatin-like domain“ (mcd-1) genes and proteins of Trichinella spiralis and T.

Type

O - Miscellaneous

CEP classification

EG - Zoology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů