Metabolomics of neurotransmitters and related metabolites in post-mortem tissue from the dorsal and ventral striatum of alcoholic human brain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00093959" target="_blank" >RIV/00216224:14310/16:00093959 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s11064-016-1830-3" target="_blank" >http://dx.doi.org/10.1007/s11064-016-1830-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11064-016-1830-3" target="_blank" >10.1007/s11064-016-1830-3</a>

Result language

angličtina

Original language name

Metabolomics of neurotransmitters and related metabolites in post-mortem tissue from the dorsal and ventral striatum of alcoholic human brain

Original language description

We report on changes in neurotransmitter metabolome and protein expression in the striatum of humans exposed to heavy long-term consumption of alcohol. Extracts from post mortem striatal tissue (dorsal striatum; DS comprising caudate nucleus; CN and putamen; P and ventral striatum; VS constituted by nucleus accumbens; NAc) were analysed by high performance liquid chromatography coupled with tandem mass spectrometry. Proteomics was studied in CN by two-dimensional gel electrophoresis followed by mass-spectrometry. Proteomics identified 25 unique molecules expressed differently by the alcohol-affected tissue. Two were dopamine- related proteins and one a GABA-synthesizing enzyme GAD65. Two proteins that are related to apoptosis and/or neuronal loss (BiD and amyloid-b A4 precursor protein-binding family B member 3) were increased.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurochemical Research

ISSN

0364-3190

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

1-2

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

385-397

UT code for WoS article

000371412800037

EID of the result in the Scopus database

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