SYNTHESIS OF FRAGRANCES STARTING FROM CYCLIC VINYL KETONES
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00108440" target="_blank" >RIV/00216224:14310/16:00108440 - isvavai.cz</a>
Result on the web
<a href="https://sciforum.net/paper/view/conference/3648" target="_blank" >https://sciforum.net/paper/view/conference/3648</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ecsoc-20-a056" target="_blank" >10.3390/ecsoc-20-a056</a>
Alternative languages
Result language
angličtina
Original language name
SYNTHESIS OF FRAGRANCES STARTING FROM CYCLIC VINYL KETONES
Original language description
Synthesis of fragrances, i.e. methyl esters and lactones of cyclic ketones, starts from cyclic vinyl ketones. These react with hydrogen cyanide in the presence of basic catalyst. Formed keto nitriles undergo a reduction of keto group in secondary hydroxy group in the next steps and process is followed by functionalization of cyano group in carboxy or alkoxycarbonyl group. The order of both processes can be exchanged. The final lactonization carry out between hydroxy and (funcionalized) carboxy group under acidic conditions.The functionalization of cyano group and subsequent lactonization take place as a one-pot process. This innovative process is simpler and cheaper and provides products in very good yields and purity, which allows further processing in the synthesis of the final products.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/TA03010633" target="_blank" >TA03010633: Advanced sustainable technologies for fine chemical syntheses based on cyanic chemistry</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů