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Maternal immunity induced by inactivated S. Typhimurium vaccine is less protective to S. Derby challenge than to S. Typhimurium challenge in suckling piglets

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00108661" target="_blank" >RIV/00216224:14310/16:00108661 - isvavai.cz</a>

  • Alternative codes found

    RIV/00027162:_____/16:N0000065

  • Result on the web

    <a href="https://www.agriculturejournals.cz/publicFiles/172753.pdf" target="_blank" >https://www.agriculturejournals.cz/publicFiles/172753.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.17221/8679-VETMED" target="_blank" >10.17221/8679-VETMED</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Maternal immunity induced by inactivated S. Typhimurium vaccine is less protective to S. Derby challenge than to S. Typhimurium challenge in suckling piglets

  • Original language description

    Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Derby are the most common serovars of Salmonella enterica ssp. enterica found in pigs in Europe. We previously observed that suckling piglets of sows vaccinated with an S. Typhimurium-based inactivated vaccine are protected against homologous strain challenge. To develop this vaccine for commercial use, potential crossprotectivity of this vaccine to challenge with S. Derby was tested. Two sows were vaccinated with an S. Typhimurium-based inactivated vaccine while two other sows remained serologically negative. Four-day-old suckling piglets from both groups were orally challenged with S. Derby or S. Typhimurium. Maternally-derived immunity against S. Typhimurium protected piglets against S. Typhimurium challenge, when a significant (P &lt; 0.05) decrease in S. Typhimurium count was found in ileocaecal and submandibular lymph node, tonsil, ileum and ileum content. On the other hand, after S. Derby challenge, significant (P &lt; 0.05) decrease in S. Derby count was detected only in ileum content. Although both serovars belong to the same O:4 serogroup, other antigenic structures, for example the flagellin, are different. In a subsequent in-vitro experiment, we found that serum from vaccinated sows inhibited the motility of S. Typhimurium but not the motility of S. Derby. Our results indicate that protectivity of S. Typhimurium vaccine against S. Derby infection is limited.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    40301 - Veterinary science

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Veterinarni Medicina

  • ISSN

    0375-8427

  • e-ISSN

    1805-9392

  • Volume of the periodical

    61

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    23-27

  • UT code for WoS article

    000376026700004

  • EID of the result in the Scopus database

    2-s2.0-84958213735