Maternal immunity induced by inactivated S. Typhimurium vaccine is less protective to S. Derby challenge than to S. Typhimurium challenge in suckling piglets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00108661" target="_blank" >RIV/00216224:14310/16:00108661 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/16:N0000065

Result on the web

<a href="https://www.agriculturejournals.cz/publicFiles/172753.pdf" target="_blank" >https://www.agriculturejournals.cz/publicFiles/172753.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/8679-VETMED" target="_blank" >10.17221/8679-VETMED</a>

Result language

angličtina

Original language name

Maternal immunity induced by inactivated S. Typhimurium vaccine is less protective to S. Derby challenge than to S. Typhimurium challenge in suckling piglets

Original language description

Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Derby are the most common serovars of Salmonella enterica ssp. enterica found in pigs in Europe. We previously observed that suckling piglets of sows vaccinated with an S. Typhimurium-based inactivated vaccine are protected against homologous strain challenge. To develop this vaccine for commercial use, potential crossprotectivity of this vaccine to challenge with S. Derby was tested. Two sows were vaccinated with an S. Typhimurium-based inactivated vaccine while two other sows remained serologically negative. Four-day-old suckling piglets from both groups were orally challenged with S. Derby or S. Typhimurium. Maternally-derived immunity against S. Typhimurium protected piglets against S. Typhimurium challenge, when a significant (P &lt; 0.05) decrease in S. Typhimurium count was found in ileocaecal and submandibular lymph node, tonsil, ileum and ileum content. On the other hand, after S. Derby challenge, significant (P &lt; 0.05) decrease in S. Derby count was detected only in ileum content. Although both serovars belong to the same O:4 serogroup, other antigenic structures, for example the flagellin, are different. In a subsequent in-vitro experiment, we found that serum from vaccinated sows inhibited the motility of S. Typhimurium but not the motility of S. Derby. Our results indicate that protectivity of S. Typhimurium vaccine against S. Derby infection is limited.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

1805-9392

Volume of the periodical

61

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

23-27

UT code for WoS article

000376026700004

EID of the result in the Scopus database

2-s2.0-84958213735