Convenient domino synthesis of quinazolin-4(3H)-ylidene carbothioamides and carbamothioates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00097013" target="_blank" >RIV/00216224:14310/17:00097013 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tet.2017.06.024" target="_blank" >http://dx.doi.org/10.1016/j.tet.2017.06.024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tet.2017.06.024" target="_blank" >10.1016/j.tet.2017.06.024</a>

Result language
angličtina
Original language name
Convenient domino synthesis of quinazolin-4(3H)-ylidene carbothioamides and carbamothioates
Original language description
A simple convenient protocol for the synthesis of secondary amine N-(2- (substitutedphenyl)quinazolin-4(3H)-ylidene) carbothioamides and O-alkyl N-2- (substitutedphenyl)quinazolin-4(3H)-ylidene carbamothioates has been described. It involves the cascade reaction of various secondary amines or alcohols with imidoylisothiocyanates in acetonitrile to afford the desired compounds in excellent yields. The reaction time was 48 h under reflux conditions, involved a simple work up, to form 42 examples of pure products in high yields. The precursor imidoyl isothiocyanates were prepared from the corresponding benzanilides and were purified by flash chromatography.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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