Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00100126" target="_blank" >RIV/00216224:14310/17:00100126 - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amepre.2016.09.026" target="_blank" >10.1016/j.amepre.2016.09.026</a>

Result language

angličtina

Original language name

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Original language description

Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p &lt; 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p &lt; 0.001) and fibrinogen (p &lt; 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p &lt; 0.05) in the fully adjusted model and C-reactive protein concentration (p &lt; 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p &lt; 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p &lt; 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AMERICAN JOURNAL OF PREVENTIVE MEDICINE

ISSN

0749-3797

e-ISSN

—

Volume of the periodical

52

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

„S63“-„S76“

UT code for WoS article

000390667100009

EID of the result in the Scopus database

2-s2.0-85008146356