In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00105752" target="_blank" >RIV/00216224:14310/18:00105752 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.estlett.8b00113" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.estlett.8b00113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.estlett.8b00113" target="_blank" >10.1021/acs.estlett.8b00113</a>
Alternative languages
Result language
angličtina
Original language name
In Vitro Inhalation Bioaccessibility of Phthalate Esters and Alternative Plasticizers Present in Indoor Dust Using Artificial Lung Fluids
Original language description
Phthalate esters (PEs) are used as plasticizers in consumer products. Their low migration stability has resulted in the classification of PEs as major indoor contaminants. Because of PE's ubiquity and adverse health effects on humans and especially children, non-phthalate alternative plasticizers have been introduced into the market. This is the first study of in vitro inhalation bioaccessibility of PEs (e.g., DMP, DEP, and DEHP) and alternative plasticizers (e.g., DEHT and DINCH) via indoor dust to assess inhalation as an alternative route of exposure. Two artificial lung fluids were used, mimicking two distinctively different pulmonary environments: (1) artificial lysosomal fluid (ALF, pH 4.5) representing the intracellular acidic lung fluid inhaled particle contact after phagocytosis by alveolar macrophages and (2) Gamble's solution (pH 7.4), the extracellular healthy fluid for deep lung deposition of dust. DMP and DEP were highly bioaccessible (>75%), whereas highly hydrophobic compounds such as DEHP, DINCH, and DEHT were <5% bioaccessible via both artificial lung fluids. Our findings show that the inhalation bioaccessibility of PEs is primarily governed by their hydrophobicity and water solubility. Further research is necessary to develop unified and biologically relevant inhalation bioaccessibility tests, employed as part of human risk assessment of volatile and semivolatile organic pollutants.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
ISSN
2328-8930
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
329-334
UT code for WoS article
000435417000006
EID of the result in the Scopus database
2-s2.0-85046546944