HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00106852" target="_blank" >RIV/00216224:14310/18:00106852 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.21101/cejph.a4921" target="_blank" >http://dx.doi.org/10.21101/cejph.a4921</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21101/cejph.a4921" target="_blank" >10.21101/cejph.a4921</a>
Alternative languages
Result language
angličtina
Original language name
HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION
Original language description
Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3'-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects. Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology. Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 +/- 29.2 g vs. 74.1 +/- 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 +/- 4.4% vs. 33.3 +/- 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage. Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European journal of public health
ISSN
1210-7778
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
272-277
UT code for WoS article
000463167100005
EID of the result in the Scopus database
2-s2.0-85060167605