Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00111943" target="_blank" >RIV/00216224:14310/18:00111943 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498802 RIV/00027162:_____/18:N0000044
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0264410X18314002?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264410X18314002?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vaccine.2018.10.034" target="_blank" >10.1016/j.vaccine.2018.10.034</a>
Alternative languages
Result language
angličtina
Original language name
Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use
Original language description
In tick-borne encephalitis (TBE) endemic areas, consumption of unpasteurized milk or milk products from grazing domestic ruminants (goats, cattle, and sheep) represents a risk of TBE virus (TBEV) infection for humans. In addition to vaccination of humans, human alimentary TBEV infections can be avoided by pasteurizing milk or by vaccination of the ruminants. However, there is presently no TBEV vaccine for veterinary use. Here, we developed a new veterinary TBE vaccine candidate based on cell culture-derived, purified, and formaldehyde-inactivated TBEV (strain Hypr). The safety and immunogenicity of the vaccine was evaluated in mice and sheep and was well-tolerated while eliciting the production of high levels of virus-neutralizing antibodies. Vaccination provided full protection against lethal TBE in mice, prevented development of viremia in sheep and presence of TBEV in milk of lactating ewes. This vaccine is a good candidate for immunization of ruminants to prevent alimentary milk-borne TBEV infections in humans.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccine
ISSN
0264-410X
e-ISSN
1873-2518
Volume of the periodical
36
Issue of the periodical within the volume
48
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
7257-7261
UT code for WoS article
000451353700001
EID of the result in the Scopus database
2-s2.0-85054738990