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Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00111943" target="_blank" >RIV/00216224:14310/18:00111943 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/18:00498802 RIV/00027162:_____/18:N0000044

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0264410X18314002?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264410X18314002?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.vaccine.2018.10.034" target="_blank" >10.1016/j.vaccine.2018.10.034</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use

  • Original language description

    In tick-borne encephalitis (TBE) endemic areas, consumption of unpasteurized milk or milk products from grazing domestic ruminants (goats, cattle, and sheep) represents a risk of TBE virus (TBEV) infection for humans. In addition to vaccination of humans, human alimentary TBEV infections can be avoided by pasteurizing milk or by vaccination of the ruminants. However, there is presently no TBEV vaccine for veterinary use. Here, we developed a new veterinary TBE vaccine candidate based on cell culture-derived, purified, and formaldehyde-inactivated TBEV (strain Hypr). The safety and immunogenicity of the vaccine was evaluated in mice and sheep and was well-tolerated while eliciting the production of high levels of virus-neutralizing antibodies. Vaccination provided full protection against lethal TBE in mice, prevented development of viremia in sheep and presence of TBEV in milk of lactating ewes. This vaccine is a good candidate for immunization of ruminants to prevent alimentary milk-borne TBEV infections in humans.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vaccine

  • ISSN

    0264-410X

  • e-ISSN

    1873-2518

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    48

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    7257-7261

  • UT code for WoS article

    000451353700001

  • EID of the result in the Scopus database

    2-s2.0-85054738990