Calcium Signaling in Liver Injury and Regeneration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00113212" target="_blank" >RIV/00216224:14310/18:00113212 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fmed.2018.00192" target="_blank" >http://dx.doi.org/10.3389/fmed.2018.00192</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmed.2018.00192" target="_blank" >10.3389/fmed.2018.00192</a>
Alternative languages
Result language
angličtina
Original language name
Calcium Signaling in Liver Injury and Regeneration
Original language description
The liver fulfills central roles in metabolic control and detoxification and, as such, is continuously exposed to a plethora of insults. Importantly, the liver has a unique ability to regenerate and can completely recoup from most acute, non-iterative insults. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), long-term alcohol abuse and chronic use of certain medications, can cause persistent injury in which the regenerative capacity eventually becomes dysfunctional, resulting in hepatic scaring and cirrhosis. Calcium is a versatile secondary messenger that regulates multiple hepatic functions, including lipid and carbohydrate metabolism, as well as bile secretion and choleresis. Accordingly, dysregulation of calcium signaling is a hallmark of both acute and chronic liver diseases. In addition, recent research implicates calcium transients as essential components of liver regeneration. In this review, we provide a comprehensive overview of the role of calcium signaling in liver health and disease and discuss the importance of calcium in the orchestration of the ensuing regenerative response. Furthermore, we highlight similarities and differences in spatiotemporal calcium regulation between liver insults of different etiologies. Finally, we discuss intracellular calcium control as an emerging therapeutic target for liver injury and summarize recent clinical findings of calcium modulation for the treatment of ischemic-reperfusion injury, cholestasis and NAFLD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN MEDICINE
ISSN
2296-858X
e-ISSN
2296-858X
Volume of the periodical
5
Issue of the periodical within the volume
JUL
Country of publishing house
SE - SWEDEN
Number of pages
17
Pages from-to
1-17
UT code for WoS article
000437327900001
EID of the result in the Scopus database
2-s2.0-85062732746