High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00107306" target="_blank" >RIV/00216224:14310/19:00107306 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/19:00071049
Result on the web
<a href="http://www.jcancer.org/v10p1393.htm" target="_blank" >http://www.jcancer.org/v10p1393.htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7150/jca.29530" target="_blank" >10.7150/jca.29530</a>
Alternative languages
Result language
angličtina
Original language name
High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma
Original language description
Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although MYB has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high MYB expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cancer
ISSN
1837-9664
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
6
Country of publishing house
AU - AUSTRALIA
Number of pages
5
Pages from-to
1393-1397
UT code for WoS article
000459711200007
EID of the result in the Scopus database
2-s2.0-85067297674