Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00107498" target="_blank" >RIV/00216224:14310/19:00107498 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/ijms20133186" target="_blank" >https://doi.org/10.3390/ijms20133186</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms20133186" target="_blank" >10.3390/ijms20133186</a>
Alternative languages
Result language
angličtina
Original language name
Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point
Original language description
The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
13
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
1-13
UT code for WoS article
000477041100074
EID of the result in the Scopus database
2-s2.0-85067211256