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Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00107498" target="_blank" >RIV/00216224:14310/19:00107498 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.3390/ijms20133186" target="_blank" >https://doi.org/10.3390/ijms20133186</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ijms20133186" target="_blank" >10.3390/ijms20133186</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

  • Original language description

    The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Molecular Sciences

  • ISSN

    1422-0067

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    13

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    13

  • Pages from-to

    1-13

  • UT code for WoS article

    000477041100074

  • EID of the result in the Scopus database

    2-s2.0-85067211256