Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00107547" target="_blank" >RIV/00216224:14310/19:00107547 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chempr.2018.11.008" target="_blank" >10.1016/j.chempr.2018.11.008</a>

Result language
angličtina
Original language name
Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters
Original language description
The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10400 - Chemical sciences

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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