Study of synthetic oligonucleotides containing guanine by circular dichroism spectroscopy and voltammetry on a pyrolytic graphite electrode

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00117919" target="_blank" >RIV/00216224:14310/19:00117919 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Study of synthetic oligonucleotides containing guanine by circular dichroism spectroscopy and voltammetry on a pyrolytic graphite electrode
Original language description
The possibility to study DNA quadruplex structures using voltammetric analysis of DNA hexamers was investigated using a pyrolytic graphite electrode in an acetate buffer (pH = 5.0). We have tested the influence of the hexamer sequence and DNA concentration their anodic oxidation. To verify the G quadruplex formation, or lack thereof, circular dichroism spectroscopy was used. Our results suggest that, on the pyrolytic graphite electrode, the guanine oxidation signals are not influenced by formation of G the quadruplex. Instead, the shape of the G oxidation multiple peak can be related to the primary structure of the oligonucleotide.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS OF THE 15TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY
ISBN
9788074440687
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
232-237
Publisher name
CHARLES UNIV, FAC SCIENCE
Place of publication
PRAGUE 2
Event location
Prague, CZECH REPUBLIC
Event date
Sep 19, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000576787700038

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