Electrochemical determination of insulin at CuNPs/chitosan-MWCNTs and CoNPs/chitosan-MWCNTs modified screen printed carbon electrodes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F20%3A00115315" target="_blank" >RIV/00216224:14310/20:00115315 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1572665720300643" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1572665720300643</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2020.113881" target="_blank" >10.1016/j.jelechem.2020.113881</a>

Result language

angličtina

Original language name

Electrochemical determination of insulin at CuNPs/chitosan-MWCNTs and CoNPs/chitosan-MWCNTs modified screen printed carbon electrodes

Original language description

Transition metal nanoparticles can be considered as promising low cost materials for insulin oxidation catalysis. Combination of transition metal nanoparticles with multi walled carbon nanotubes (MWCNTs), which enlarges the active surface area of the electrode, can improve the analytical characteristics of electrodes. Two types of screen printed carbon electrodes (SPCEs) modified by the combination of copper (CuNPs) or cobalt (CoNPs) nanoparticles with chitosan and MWCNTs were prepared. In the effort to find the most suitable modification for electrochemical insulin determination, stability, analytical characteristics and selectivity of both electrode types were compared. The results proved better stability and analytical characteristics with no significant influence of interferences on insulin determination at CoNPs/chitosan-MWCNTs/SPCE. These electrodes provided low limit of detection (25 nM), high sensitivity (0.031 mA uM-1) and wide linear range (0.05 uM to 5 uM) for insulin determination. The stability of the CoNPs/chitosan-MWCNTs/SPCE was very high, with only 1.7% decrease of maximal current value after 50 measurements. Therefore, CoNPs/chitosan-MWCNTs/SPCE can be considered as the suitable modification for new electrochemical sensor for insulin determination, with better analytical characteristics in comparison with SPCE modification using MWCNTs, chitosan and CuNPs described in this study.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/LM2015043" target="_blank" >LM2015043: Czech Infrastructure for Integrative Structural Biology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Electroanalytical Chemistry

ISSN

1572-6657

e-ISSN

1873-2569

Volume of the periodical

860

Issue of the periodical within the volume

MAR 1 2020

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000519336100002

EID of the result in the Scopus database

2-s2.0-85078493165