Refining the resolution of craniofacial dysmorphology in bipolar disorder as an index of brain dysmorphogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F20%3A00117604" target="_blank" >RIV/00216224:14310/20:00117604 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.psychres.2020.113243" target="_blank" >https://doi.org/10.1016/j.psychres.2020.113243</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.psychres.2020.113243" target="_blank" >10.1016/j.psychres.2020.113243</a>
Alternative languages
Result language
angličtina
Original language name
Refining the resolution of craniofacial dysmorphology in bipolar disorder as an index of brain dysmorphogenesis
Original language description
As understanding of the genetics of bipolar disorder increases, controversy endures regarding whether the origins of this illness include early maldevelopment. Clarification would be facilitated by a 'hard' biological index of fetal developmental abnormality, among which craniofacial dysmorphology bears the closest embryological relationship to brain dysmorphogenesis. Therefore, 3D laser surface imaging was used to capture the facial surface of 21 patients with bipolar disorder and 45 control subjects; 21 patients with schizophrenia were also studied. Surface images were subjected to geometric morphometric analysis in non-affine space for more incisive resolution of subtle, localised dysmorphologies that might distinguish patients from controls. Complex and more biologically informative, non-linear changes distinguished bipolar patients from control subjects. On a background of minor dysmorphology of the upper face, maxilla, midface and periorbital regions, bipolar disorder was characterised primarily by the following dysmorphologies: (a) retrusion and shortening of the premaxilla, nose, philtrum, lips and mouth (the frontonasal prominences), with (b) some protrusion and widening of the mandible-chin. The topography of facial dysmorphology in bipolar disorder indicates disruption to early development in the frontonasal process and, on embryological grounds, cerebral dysmorphogenesis in the forebrain, most likely between the 10th and 15th week of fetal life.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychiatry Research
ISSN
0165-1781
e-ISSN
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Volume of the periodical
291
Issue of the periodical within the volume
September 2020
Country of publishing house
IE - IRELAND
Number of pages
6
Pages from-to
1-6
UT code for WoS article
000566872600077
EID of the result in the Scopus database
2-s2.0-85087068317