Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00118907" target="_blank" >RIV/00216224:14310/21:00118907 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/21:00537040
Result on the web
<a href="https://doi.org/10.3390/ijms22020501" target="_blank" >https://doi.org/10.3390/ijms22020501</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22020501" target="_blank" >10.3390/ijms22020501</a>
Alternative languages
Result language
angličtina
Original language name
Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
Original language description
The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA19-16861S" target="_blank" >GA19-16861S: Interaction of biomaterials with stem cells under in vivo simulated conditions</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
„501“
UT code for WoS article
000611321200001
EID of the result in the Scopus database
2-s2.0-85099135097