A cellular and spatial map of the choroid plexus across brain ventricles and ages
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00119006" target="_blank" >RIV/00216224:14310/21:00119006 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00544117
Result on the web
<a href="https://doi.org/10.1016/j.cell.2021.04.003" target="_blank" >https://doi.org/10.1016/j.cell.2021.04.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cell.2021.04.003" target="_blank" >10.1016/j.cell.2021.04.003</a>
Alternative languages
Result language
angličtina
Original language name
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Original language description
The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1 beta (IL-1 beta) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell
ISSN
0092-8674
e-ISSN
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Volume of the periodical
184
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
40
Pages from-to
„3056-3074“,„e1-e21“
UT code for WoS article
000656965600019
EID of the result in the Scopus database
2-s2.0-85106858617