Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00119125" target="_blank" >RIV/00216224:14310/21:00119125 - isvavai.cz</a>
Alternative codes found
RIV/68081766:_____/21:00544056 RIV/00209805:_____/21:00078964 RIV/00216208:11310/21:10434284
Result on the web
<a href="https://doi.org/10.3354/dao03601" target="_blank" >https://doi.org/10.3354/dao03601</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3354/dao03601" target="_blank" >10.3354/dao03601</a>
Alternative languages
Result language
angličtina
Original language name
Swim bladder as a primary site of mycobacterial infection in Nothobranchius 'belly sliders'
Original language description
The swim bladder inflates early after fish hatching via its interconnection with the digestive tract (ductus pneumaticus). This interconnection may serve as a portal to foreign particles, including bacteria, causing deficiencies in primary swim bladder inflation. We histologically examined 134 African annual killifish (genus Nothobranchius) with secondary loss of swim bladder function ('belly sliders'). We demonstrate that these fish lost the ability of air regulation in their swim bladders likely due to Mycobacterium spp. infection at an individual-specific age. Nearly all examined belly sliders had thickened swim bladder walls, and their swim bladder was filled with material containing mycobacteria, cell debris, young monocytic cells and phagocyting macrophages. Mycobacterial infection was restricted to the swim bladder in juveniles, where mycobacteria likely enter the host through the ductus pneumaticus. Infection in adults was systemic and mycobacteria were present in all examined organs. Presence of mycobacteria in the epithelial lining and submucosal layers of the digestive tract of adults suggests that it may also serve as the entrance site of infection. We suspect 2 sources of Mycobacterium contamination: dietary (with bloodworms) and/or contaminated hatching substrate. These sources of contamination may be eliminated by use of laboratory dry feed and egg disinfection prior to hatching.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10618 - Ecology
Result continuities
Project
<a href="/en/project/GA19-20873S" target="_blank" >GA19-20873S: Driver mutations in cancer genome of Nothobranchius furzeri: from tumor biology to concept of experimental model of spontaneous carcinogenesis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diseases of aquatic organisms
ISSN
0177-5103
e-ISSN
1616-1580
Volume of the periodical
145
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
111-117
UT code for WoS article
000691780800010
EID of the result in the Scopus database
2-s2.0-85104155322