Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00123816" target="_blank" >RIV/00216224:14310/21:00123816 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007/164_2021_527" target="_blank" >https://link.springer.com/chapter/10.1007/164_2021_527</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/164_2021_527" target="_blank" >10.1007/164_2021_527</a>
Alternative languages
Result language
angličtina
Original language name
Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
Original language description
Dishevelled (DVL) is the central signal transducer in both Wnt/β-catenin-dependent and independent signalling pathways. DVL is required to connect receptor complexes and downstream effectors. Since proximal Wnt pathway components and DVL itself are upregulated in many types of cancer, DVL represents an attractive therapeutic target in the Wnt-addicted cancers and other disorders caused by aberrant Wnt signalling. Here, we discuss progress in several approaches for the modulation of DVL function and hence inhibition of the Wnt signalling. Namely, we sum up the potential of modulation of enzymes that control post-translational modification of DVL - such as inhibition of DVL kinases or promotion of DVL ubiquitination and degradation. In addition, we discuss research directions that can take advantage of direct interaction with the protein domains essential for DVL function: the inhibition of DIX- and DEP-domain mediated polymerization and interaction of DVL PDZ domain with its ligands.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/EF16_025%2F0007381" target="_blank" >EF16_025/0007381: Preclinical Progression of New Organic Compounds with Targeted Biological Activity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Pharmacology of the WNT Signaling System
ISBN
9783030854980
Number of pages of the result
19
Pages from-to
117-135
Number of pages of the book
422
Publisher name
Springer
Place of publication
Cham (Švýcarsko)
UT code for WoS chapter
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