bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00126912" target="_blank" >RIV/00216224:14310/22:00126912 - isvavai.cz</a>
Result on the web
<a href="https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4" target="_blank" >https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2022.105364" target="_blank" >10.1016/j.isci.2022.105364</a>
Alternative languages
Result language
angličtina
Original language name
bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana
Original language description
Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10600 - Biological sciences
Result continuities
Project
<a href="/en/project/EF17_050%2F0008496" target="_blank" >EF17_050/0008496: MSCAfellow@MUNI</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ISCIENCE
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
25
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
105364
UT code for WoS article
000964036200006
EID of the result in the Scopus database
2-s2.0-85140805385